High periostin expression in gastric cancer stroma is significantly associated with worse survival, higher recurrence rates, and higher disease stage (all p<0.001).
Is periostin expression on tumor stromal cells associated with malignant progression in patients with gastric cancer?
Periostin expression on tumor stromal fibroblasts is significantly associated with malignant progression and worse survival in gastric cancer.
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Abstract Periostin is one of matrix cellular proteins. It has been reported that the periostin in the tumor microenvironment might regulate the FAK signaling via the interaction with integrins expressed on cancer cells, resulting in the stimulation of proliferation and invasion. In gastric cancer (GC), the periostin has reported to be overexpressed in the tumor stroma, however, the role of periostin and the types of cells remains to be unclear. Then, in this study we examined the significance of periostin on the clinico-pathologic features of GC by immunohistochemical study, using 689 GC samples. Also, 4 GC cell lines were used to examine the effect of periostin on the proliferation and the invasion activity of GC cells by proliferation assay and invasion assay.The immunohistochemical study of periostin confirmed that the expression of periostin was frequently found on stromal fibroblasts in the tumor. High expression of periostin in the tumor stroma is associated with worse survival rates (p 0.001, log-rank), deeper T invasion (p 0.001), frequent lymph node metastasis (p 0.001), distant metastasis (p = 0.021), higher recurrence rates (p 0.001), and higher stage (p 0.001). In vitro assays using GC cell lines demonstrated that periostin significantly promoted the invasion and migration ability of GC cells, but did not affect the proliferation activity.In conclusion, the periostin, which is mainly expressed on the tumor stromal fibroblasts, might be associated with the malignant progression of GC. Citation Format: Canfeng Fan, Hinano Nishikubo, DONGHENG MA, Tomoya Sano, Daiki Imanishi, Takashi Sakuma, Yurie Yamamoto, Masakazu Yashiro. Periostin on tumor stromal cells might be associated with the malignant progression of patients with gastric cancer abstract. In: Proceedings of the American Association for Cancer Research Annual Meeting 2026; Part 1 (Regular Abstracts); 2026 Apr 17-22; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2026;86(7 Suppl):Abstract nr 3921.
Fan et al. (Fri,) reported a other. High periostin expression in gastric cancer stroma is significantly associated with worse survival, higher recurrence rates, and higher disease stage (all p<0.001).