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April 7, 2026Radiotherapy and Oncology2 citationsOpen Access

Radiation therapy management in BRCA1/2 carriers diagnosed with early breast cancer: An international cohort study

CBCarlotta BecheriniEBEva BlondeauxVDVirginia Delucchi

Key Points

  • To evaluate the effectiveness of radiation therapy in BRCA1/2 carriers diagnosed with early breast cancer.
  • Analyzed data from the largest international cohort of BRCA1/2 carriers diagnosed with breast cancer at age 40
  • Compared outcomes of breast-conserving surgery plus radiation therapy versus mastectomy alone
  • Assessed overall survival and rates of breast events
  • Overall survival rates were similar for breast-conserving surgery plus radiation therapy and mastectomy alone
  • Breast-conserving surgery with radiation therapy led to more ipsilateral and contralateral breast events compared to mastectomy
  • Findings suggest a need for individualized, multidisciplinary treatment approaches for young BRCA carriers

Abstract

Largest international cohort of BRCA1/2 carriers diagnosed with breast cancer at 40 years.OS was similar after BCS plus RT versus MS alone.BCS plus RT was associated with more ipsilateral and contralateral breast events than MS alone.Findings support individualised, multidisciplinary loco-regional decision-making in young BRCA carriers.

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Cite This Study

Becherini et al. (2026) studied this question.

synapsesocial.com/papers/69d49f1cb33cc4c35a227951https://doi.org/10.1016/j.radonc.2026.111523
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