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March 16, 2016Circulation464 citationsOpen Access

Doxorubicin Blocks Cardiomyocyte Autophagic Flux by Inhibiting Lysosome Acidification

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DLDan L. LiZWZhao V. WangGDGuanqiao Ding

Structured PICO

P
Population
Cardiomyocytes
I
Intervention
Doxorubicin exposure and reduction of autophagy initiation
O
Outcome
Autophagic flux, lysosome acidification, lysosomal function, and cardiotoxicitysurrogate

Doxorubicin-induced cardiotoxicity is mediated by impaired lysosomal acidification and blocked autophagic flux, suggesting that reducing autophagy initiation may offer a protective strategy.

Abstract

Doxorubicin blocks autophagic flux in cardiomyocytes by impairing lysosome acidification and lysosomal function. Reducing autophagy initiation protects against doxorubicin cardiotoxicity.

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Cite This Study

Li et al. (2016) studied this question.

synapsesocial.com/papers/69d56e1675589c71d767d37dhttps://doi.org/10.1161/circulationaha.115.017443
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