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June 22, 2012Circulation Research199 citationsOpen Access

Stimulated Emission Depletion Live-Cell Super-Resolution Imaging Shows Proliferative Remodeling of T-Tubule Membrane Structures After Myocardial Infarction

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EWEva WagnerMLMarcel A. LauterbachTKTobias Kohl

Structured PICO

P
Population
Preclinical model of early heart failure (HF) development after myocardial infarction (specific animal/cell model not stated in abstract)
I
Intervention
Stimulated Emission Depletion (STED) nanoscopy for live mapping of T-tubule (TT) membrane structures
O
Outcome
T-tubule (TT) morphology, associated proteins, network remodeling, and Ca(2+) release dyssynchronysurrogate

Live-cell STED nanoscopy demonstrates that early heart failure development after myocardial infarction is characterized by proliferative T-tubule membrane changes, network fracturing, and excitation-contraction uncoupling.

Abstract

This study introduces STED nanoscopy for live mapping of TT membrane structures. During early HF development, the local TT morphology and associated proteins were significantly altered, leading to differential network remodeling and Ca(2+) release dyssynchrony. Our data suggest that TT remodeling during HF development involves proliferative membrane changes, early excitation-contraction uncoupling, and network fracturing.

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Cite This Study

Wagner et al. (2012) studied this question.

synapsesocial.com/papers/69d56ecc75589c71d767d675https://doi.org/10.1161/circresaha.112.274530
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Also Consider

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  1. 1Remodeling of T-Tubules and Reduced Synchrony of Ca 2+ Release in Myocytes From Chronically Ischemic Myocardium2007 · 226 citations
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  4. 4Examination of the Transverse Tubular System in Living Cardiac Rat Myocytes by 2-Photon Microscopy and Digital Image–Processing Techniques1999 · 333 citations
  5. 5Subcellular [Ca 2+ ] i Gradients During Excitation-Contraction Coupling in Newborn Rabbit Ventricular Myocytes1999 · 166 citations