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July 1, 2016Circulation Arrhythmia and Electrophysiology111 citationsOpen Access

Signal Transducer and Activator of Transcription 3/MicroRNA-21 Feedback Loop Contributes to Atrial Fibrillation by Promoting Atrial Fibrosis in a Rat Sterile Pericarditis Model

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ZHZhengrong HuangXCXiaojun ChenCQCheng Qian

Structured PICO

P
Population
Rat sterile pericarditis model
O
Outcome
Atrial fibrillation and atrial fibrosissurrogate

Identified a STAT3/miR-21 feedback loop that promotes atrial fibrosis and contributes to atrial fibrillation in a rat model of sterile pericarditis.

Abstract

Our results have uncovered a novel reciprocal loop between STAT3 and miR-21 that is activated after heart surgery and can contribute to atrial fibrillation.

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Cite This Study

Huang et al. (2016) studied this question.

synapsesocial.com/papers/69d573169d980f6498ccb29chttps://doi.org/10.1161/circep.115.003396
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