April 18, 2013Open Access

Pharmacology of levosimendan: inotropic, vasodilatory and cardioprotective effects

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Levosimendan and its active metabolite OR-1896

This review summarizes the pharmacological characteristics of levosimendan and its active metabolite OR-1896, focusing on their inotropic, vasodilatory, and cardioprotective effects.

Abstract

This review summarizes the characteristics and the current knowledge of the literature on levosimendan and its active metabolite OR-1896.

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Pathak et al. (Thu,) studied this question.

synapsesocial.com/papers/69d573fccb7e4bf698cf405b https://doi.org/https://doi.org/10.1111/jcpt.12067

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Effects of Levosimendan, a Cardiotonic Agent Targeted to Troponin C, on Cardiac Function and on Phosphorylation and Ca<sup>2+</sup>Sensitivity of Cardiac Myofibrils and Sarcoplasmic Reticulum in Guinea Pig Heart1995 · 235 citations
2The Effectiveness and Relative Effectiveness of Intravenous Inotropic Drugs Acting Through the Adrenergic Pathway in Patients with Heart Failure—A Meta-Regression Analysis2002 · 318 citations
3Effects of Levosimendan on Left Ventricular Relaxation and Early Filling at Maintained Preload and Afterload Conditions After Aortic Valve Replacement for Aortic Stenosis2008 · 92 citations
4Pharmacokinetics of levosimendan and its metabolites during and after a 24-hour continuous infusion in patients with severe heart failure2002 · 198 citations
5The Cardioprotective Effects of Levosimendan: Preclinical and Clinical Evidence2007 · 97 citations

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