This represents the first reported case of familial CRPS in pediatric siblings, demonstrating the complex interplay between environmental triggers and genetic susceptibility in CRPS pathogenesis. The case highlights the importance of systematic differential diagnosis in pediatric extremity pain and demonstrates the efficacy of early aggressive treatment with Gabapentin and IVIG in pediatric CRPS (Mangnus et al. in Drugs 82(5):511531, 2022; Goebel et al. in Ann Intern Med 152(3):152-158, 2010).
Al-Kateb et al. (2026) studied this question.