PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
Synapse
⌘+K
Synapse
April 8, 2026Virology JournalOpen Access

The viral and host genomic landscape of human T-cell leukemia virus type I in Peru

View Full Paper
Ask AI
Bookmark
Share

Authors

DEDaniel Jair Enriquez-VeraJLJiazhou LiJNJorge Nakazaki-Aza

Discussion

Loading...

Member takes

Overview

Prospective cohort study identifies unique viral evolution and risk factors in HTLV-1 infected individuals.

Key Points

  • This research aims to characterize the genomic and immunological features of HTLV-1 in Peru, focusing on population-specific risks.
  • Conducted a prospective cohort study with 67 HTLV-1 infected individuals from Lima, Peru.
  • Used high-throughput genomic approaches including whole-genome HTLV-1 sequencing.
  • Performed high-resolution HLA typing and targeted sequencing of hematological malignancy-associated genes.
  • Executed phylogenomic analyses with maximum likelihood and Bayesian methods.
  • Followed clinical outcomes for 7 years.
  • Median proviral load was 4.5 ± 3.8 with a 13.4% cumulative crude mortality over 7 years.
  • Most isolates (96.8%) belonged to the Transcontinental subtype, clustering in a new Andean-Amazonian subgroup.
  • Unique population-specific allele distributions revealed significantly reduced evolutionary divergence compared to Japanese cohorts.
  • Identified early clonal hematopoiesis with prevalent mutations in cancer-associated genes such as KMT2D (55%) and NOTCH1 (49%).
  • Proviral load was the only independent predictor of crude mortality, with a significant correlation to mutation burden.

Cite This Study

Enriquez-Vera et al. (2026) studied this question.

synapsesocial.com/papers/69d5f17974eaea4b11a7afbahttps://doi.org/10.1186/s12985-026-03148-8
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Epidemiology of adult t-cell leukemia/lymphoma in people living with HTLV-1: A 30-year study in Peru2026
  2. 2HTLV-1 and ATLL: Opportunities for Community-Informed Research in the United States2025 · 1 citations
  3. 3HTLV-1 and ATLL: Epidemiology, Oncogenesis, and Opportunities for Community-Informed Research in the United States2025 · 8 citations
  4. 4P-188. Intrafamilial Aggregation of Adult T-Cell Leukemia Among HTLV-1 Carriers in Peru2026
  5. 5High Rate of Human T-Cell Lymphotropic Virus-2 in Patients with HIV in the Peruvian Amazon2025 · 2 citations