Does deletion of type VI collagen improve cardiac function and remodeling after myocardial infarction in a knockout model?
Deletion of type VI collagen paradoxically protects the heart after myocardial infarction by limiting infarct size and adverse remodeling.
These unexpected results demonstrate for the first time that deletion of type VI collagen in this knockout model plays a critical protective role after MI by limiting infarct size, chronic apoptosis, aberrant remodeling, and fibrosis, leading to preservation of cardiac function.
Luther et al. (Fri,) studied this question.