The incidence of propofol-related infusion syndrome in critically ill adults slightly exceeds 1%, highlighting a measurable risk in this population.
Despite using a conservative definition for PRIS, and only considering new-onset PRIS clinical manifestations, the incidence of PRIS slightly exceeds 1%. Future controlled studies focusing on evaluating whether propofol manifests the derangements of critical illness more frequently than other sedatives will need to be large. These studies should also investigate the mechanism(s) and risk factors for PRIS.
Roberts et al. (Thu,) studied this question.