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April 28, 2025BMJ381 citationsOpen Access

SPIRIT 2025 statement: updated guideline for protocols of randomised trials

ACAn‐Wen ChanIBIsabelle BoutronSHSally Hopewell

Key Points

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Abstract

Widespread endorsement and adherence to the updated SPIRIT 2025 statement have the potential to enhance the transparency and completeness of trial protocols for the benefit of investigators, trial participants, patients, funders, research ethics committees, journals, trial registries, policymakers, regulators, and other reviewers.

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Chan et al. (2025) studied this question.

synapsesocial.com/papers/69d766f1db9d5e1bf4b8a333https://doi.org/10.1136/bmj-2024-081477
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The effect of study type on research ethics committees’ queries in medical studies2016 · 15 citations
  2. 2Methods used to develop the SPIRIT 2024 and CONSORT 2024 Statements2024 · 41 citations
  3. 3Promoting public access to clinical trial protocols: challenges and recommendations2018 · 85 citations
  4. 4Review and publication of protocol submissions to Trials – what have we learned in 10 years?2016 · 74 citations
  5. 5SPIRIT 2013 Statement: Defining Standard Protocol Items for Clinical Trials2013 · 8,112 citations