ODQ is a selective inhibitor of soluble guanylyl cyclase that blocks NO-mediated vasodilation in mouse cerebral arterioles without generating superoxide anions.
Thus, nitric oxide-mediated dilatation of mouse cerebral arterioles is profoundly inhibited by ODQ, an inhibitor of activity of soluble guanylyl cyclase. Cerebral vasodilator responses to adenosine and 8-bromo-cGMP were preserved in the presence of ODQ, indicating that inhibition by ODQ was selective. In contrast to previously used inhibitors of soluble guanylyl cyclase (methylene blue and LY-83583), the effects of ODQ are not mediated by generation of superoxide anion.
Sobey et al. (Tue,) studied this question.