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August 16, 2000Journal of Clinical Oncology3,829 citations

Leucovorin and Fluorouracil With or Without Oxaliplatin as First-Line Treatment in Advanced Colorectal Cancer

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AGAimery de GramontInstitut Hospitalier Franco BritanniqueAFArié FigerOntario Institute for Cancer ResearchMSMichel SeymourUniversity of Leeds

Key Points

  • This research aims to evaluate the effectiveness of the LV5FU2-oxaliplatin regimen as a first-line treatment for advanced colorectal cancer.
  • Utilized LV5FU2-oxaliplatin as the treatment regimen.
  • Assessed progression-free survival.
  • Evaluated quality of life during treatment.
  • The LV5FU2-oxaliplatin combination improved progression-free survival compared to standard treatment.
  • The regimen was well-tolerated with acceptable side effects.
  • Quality of life was maintained during the treatment period.

Abstract

The LV5FU2-oxaliplatin combination seems beneficial as first-line therapy in advanced colorectal cancer, demonstrating a prolonged progression-free survival with acceptable tolerability and maintenance of QoL.

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Cite This Study

Gramont et al. (2000) studied this question.

synapsesocial.com/papers/69d7cd4e319e71454dbedabbhttps://doi.org/10.1200/jco.2000.18.16.2938
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