Summarize the chemical diversity, taxonomic distribution, biosynthetic routes, and biological roles of natural products containing nitrile functional groups.
Systematic review of chemical structures and metabolic sources of natural nitriles across bacteria, fungi, plants, and marine invertebrates.
Evaluation of enzymatic pathways and mechanisms involved in nitrile formation.
Nitrile functionalities occur widely across cyanogenic glycosides, alkaloids, nonribosomal peptides, and polyketides.
Key enzymatic pathways, including aldoxime dehydratases and cytochrome P450 monooxygenases, mediate nitrile assembly from amino acid precursors.
Naturally occurring nitriles frequently demonstrate potent biological functions, including chemical defense, antimicrobial properties, and anticancer activities.
Abstract
The first page of this article is displayed as the abstract.