iCa²⁺ changes dynamically during trauma and resuscitation, in parallel with alterations in acid-base status, circulating ions, transfusion, and endocrine responses. iCa²⁺ can spontaneously recover to baseline with adequate resuscitation without calcium supplementation. This exploratory study can contribute to the development of a robust experimental model for future translational research. (J Trauma Acute Care Surg. 2026;00:00-00. Copyright © 2026 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Association for the Surgery of Trauma.).
Helsloot et al. (Mon,) studied this question.