What question did this study set out to answer?

This research aims to explore how accelerated epigenetic aging impacts cognitive decline associated with homocysteine levels.

April 10, 2026Alzheimer s & Dementia1 citationsOpen Access

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Accelerated epigenetic aging as a modifier of homocysteine‐associated cognitive decline: Findings from NHANES

HLHaoxuan LiHebei Medical University YCYuhan ChenHebei Medical University ZWZhe WangHebei Medical University

Key Points

This research aims to explore how accelerated epigenetic aging impacts cognitive decline associated with homocysteine levels.
Analyzed data from NHANES
Assessed the relationship between homocysteine and cognitive function
Investigated the role of epigenetic aging and neuroinflammation
Higher homocysteine levels are linked to increased cognitive decline.
Epigenetic aging exacerbates the cognitive effects of hyperhomocysteinemia.
Folate shows protective effects by lowering homocysteine levels.

Abstract

Epigenetic aging-associated neuroinflammation serves as a key mechanistic link between hyperhomocysteinemia and cognitive decline. The neuroprotective effects of folate are mediated specifically through homocysteine reduction, providing novel mechanistic insights for precision prevention strategies in cognitive aging.

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Accelerated epigenetic aging as a modifier of homocysteine‐associated cognitive decline: Findings from NHANES

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