Targeted elimination of CD44 + prostate cancer stem cells using hyaluronic acid-coated selenium nanoparticles co-loaded with apigenin

Key Points

• The research aims to explore a method for targeting and eliminating CD44+ prostate cancer stem cells.
• Utilized hyaluronic acid-coated selenium nanoparticles as a delivery vehicle.
• Co-loaded nanoparticles with apigenin to enhance therapeutic effects.
• Evaluated the impact on stemness and apoptosis in castration-resistant prostate cancer cells.
• Significant suppression of stemness observed among treated cancer stem cells.
• Enhanced apoptotic elimination of these cells was achieved with the nanoparticle treatment.