What question did this study set out to answer?

This research aims to develop a visible-light-driven protocol for functionalizing N-aryl pyrrolidines and piperidines.

April 10, 2026Open Access

Photoredox-enabled late-stage functionalization of pyrrolidines in batch and flow: rapid access to benzothiazole hybrids as a new class of cholinesterase inhibitors

Key Points

This research aims to develop a visible-light-driven protocol for functionalizing N-aryl pyrrolidines and piperidines.
Developed a photoredox protocol using visible light for reactions
Conducted heteroarylation of N-aryl pyrrolidines and piperidines
Performed experiments in both batch and flow conditions
Successfully synthesized benzothiazole derivatives as new cholinesterase inhibitors
Demonstrated rapid access to functionalized compounds
Achieved the reaction using the novel photoredox method

Abstract

A visible-light-driven photoredox protocol for the α-amino C(sp 3 )–H heteroarylation of N -aryl pyrrolidines and piperidines with 2-chlorobenzothiazole derivatives in batch and in flow conditions is developed.

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Journals

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Institutions

University of Belgrade

Institute of Chemistry, Technology and Metallurgy

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