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April 10, 2026RSC Advances0 citationsOpen Access

Photoredox-enabled late-stage functionalization of pyrrolidines in batch and flow: rapid access to benzothiazole hybrids as a new class of cholinesterase inhibitors

AFA. FilipovićUniversity of BelgradeMVMarija VučkovskiUniversity of BelgradeDMD. MićovićUniversity of Belgrade

Key Points

  • This research aims to develop a visible-light-driven protocol for functionalizing N-aryl pyrrolidines and piperidines.
  • Developed a photoredox protocol using visible light for reactions
  • Conducted heteroarylation of N-aryl pyrrolidines and piperidines
  • Performed experiments in both batch and flow conditions
  • Successfully synthesized benzothiazole derivatives as new cholinesterase inhibitors
  • Demonstrated rapid access to functionalized compounds
  • Achieved the reaction using the novel photoredox method

Abstract

A visible-light-driven photoredox protocol for the α-amino C(sp 3 )–H heteroarylation of N -aryl pyrrolidines and piperidines with 2-chlorobenzothiazole derivatives in batch and in flow conditions is developed.

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Cite This Study

Filipović et al. (2026) studied this question.

synapsesocial.com/papers/69d893eb6c1944d70ce04d55https://doi.org/10.1039/d6ra01041e
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