Application of N6-Macrocycles in Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation and Asymmetric Hydrogenation of Aromatic Ketones

Key Points

• The research aims to enhance catalytic activity and enantioselectivity in asymmetric hydrogenation reactions using N6-macrocyclic ligands.
• Utilized C2-symmetric N6-chiral macrocyclic ligands.
• Conducted ruthenium-catalyzed transfer hydrogenation and hydrogenation of aromatic ketones.
• Analyzed enantiomeric excess and yield of chiral alcohols produced.
• Achieved up to 99% separation yield of products.
• Obtained enantiomeric excess up to 95%.
• Demonstrated superior catalytic activity and enantioselectivity compared to linear analogs.