PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
April 10, 2026The Laryngoscope0 citations

Limitations of Raised Thyroglobulin: Two Cases of Benign Lymphadenopathy Mimicking Thyroid Carcinoma

View Full Paper
SGShireen S. GohariMassachusetts Eye and Ear InfirmaryIWIsaac WassermanMassachusetts Eye and Ear InfirmaryJPJustine PhilteosMassachusetts Eye and Ear Infirmary

Key Points

  • This research aims to explore the reliability of elevated thyroglobulin washout in diagnosing thyroid cancer.
  • Presented two case reports of patients with elevated thyroglobulin washout
  • Documented patient history including iron-handling disorders
  • Analyzed histopathological findings of cervical lymph nodes
  • Both cases had benign lymphadenopathy despite high thyroglobulin levels
  • Iron-handling disorders may complicate the interpretation of thyroglobulin levels
  • Findings indicate the need for multimodal interpretation in clinical practice

Abstract

Markedly elevated thyroglobulin (Tg) washout is often considered highly suggestive of metastatic differentiated thyroid cancer. We present two cases of false-positive Tg washout in cervical lymph nodes with benign pathology, notably in patients who were carriers of iron-handling disorders. These findings highlight the limitations of Tg washout as a standalone marker and the need for multimodal interpretation.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Gohari et al. (2026) studied this question.

synapsesocial.com/papers/69d894326c1944d70ce051a7https://doi.org/10.1002/lary.70556
Ask AI
Helpful
Bookmark
Share
View Full Paper