Hyperoside Modulates the Estrogen‐PI3K/VEGF Axis to Ameliorate Oxidative Damage‐Induced Inhibition of Bone Formation in MC3T3‐E1 Cells

Key Points

• The study aims to explore how hyperoside influences the estrogen-PI3K/VEGF signaling pathway to enhance bone formation.
• MC3T3-E1 cells were cultured to simulate osteoblast differentiation.
• Hyperoside was applied to assess its effects on oxidative stress and bone formation.
• The estrogen-PI3K/VEGF signaling pathway was analyzed for regulatory changes.
• Hyperoside significantly reduced oxidative stress in MC3T3-E1 cells.
• It promoted osteoblast differentiation and enhanced bone formation.
• Activation of the estrogen-PI3K/VEGF pathway was observed in treated cells.