What question did this study set out to answer?

The study aims to investigate how ZhiXiaoSanZheng formula impacts podocyte injury in diabetic kidney disease through ferroptosis modulation.

April 10, 2026Chinese Medicine0 citationsOpen Access

ZhiXiaoSanZheng formula ameliorates podocyte injury in diabetic kidney disease by inhibiting ferroptosis: integrated network pharmacology and experimental validation

SZShaofeng ZhouFujian University of Traditional Chinese Medicine HZHuijuan ZhengBeijing University of Chinese Medicine XZXinghua ZhangBeijing University of Chinese Medicine

Key Points

The study aims to investigate how ZhiXiaoSanZheng formula impacts podocyte injury in diabetic kidney disease through ferroptosis modulation.
Utilized network pharmacology to identify key pathways involved.
Conducted experimental validation to assess the effects of ZXSZF.
Focused on the NRF2/SLC7A11/GPX4 pathway related to ferroptosis.
ZXSZF significantly alleviated podocyte injury in diabetic kidney disease.
The renoprotective effects were linked to modulation of ferroptosis-related pathways.
Supportive evidence highlighted the NRF2/SLC7A11/GPX4 pathway's role in the process.

Abstract

ZXSZF alleviates podocyte injury in DKD and its renoprotective effects are associated with modulation of ferroptosis-related processes involving the NRF2/SLC7A11/GPX4 pathway. The present study provides experimental evidence for the mechanistic basis of ZXSZF and supports its potential role as a complementary therapeutic option in DKD management.

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