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April 10, 2026RSC Advances2 citationsOpen Access

Fabrication of methotrexate conjugated multi-walled carbon nanotubes for the evaluation of cytotoxic potential at biochemical and molecular level modulating BAX , BCL-2 and telomerase expression

HTHarshita TiwariCzech Academy of Sciences, Institute of Experimental MedicineSSSwati SinghIndira Gandhi Institute of Medical SciencesVKVandana KumariInstitute of Medical Sciences

Key Points

  • The aim is to evaluate the cytotoxic effects of methotrexate-conjugated multi-walled carbon nanotubes at the biochemical and molecular levels.
  • Fabricated methotrexate-multi-walled carbon nanotube nanoconjugate.
  • Characterized the nanoconjugate for various properties.
  • Conducted in vitro assays to assess cytotoxic activity, hemocompatibility, and anti-angiogenic effects.
  • The MTX-MWCNT nanoconjugate exhibited significant cytotoxic activity.
  • Altered expression levels of BAX and BCL-2 were observed.
  • Demonstrated potential for anti-angiogenic effects through morphological alterations.

Abstract

Fabrication and characterization of MTX-MWCNT nanoconjugate for evaluation of its cytotoxic activity, hemocompatibility, anti-angiogenic potential, molecular expression and morphological alterations through in vitro assays.

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Cite This Study

Tiwari et al. (2026) studied this question.

synapsesocial.com/papers/69d895ea6c1944d70ce07074https://doi.org/10.1039/d5ra08838k
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