Fabrication of methotrexate conjugated multi-walled carbon nanotubes for the evaluation of cytotoxic potential at biochemical and molecular level modulating BAX , BCL-2 and telomerase expression

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Methotrexate-conjugated multi-walled carbon nanotubes (MTX-MWCNT) demonstrate cytotoxic and anti-angiogenic potential through the modulation of BAX, BCL-2, and telomerase expression. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Harshita Tiwari; Swati Singh; Vandana Kumari; Shikha Tripathi; Anurag Kumar Singh; Avanish Singh Parmar; Santosh Kumar Singh; Vidhi Gautam

doi:10.1039/d5ra08838k

January 1, 2026RSC AdvancesOpen Access

Fabrication of methotrexate conjugated multi-walled carbon nanotubes for the evaluation of cytotoxic potential at biochemical and molecular level modulating BAX , BCL-2 and telomerase expression

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Key Points

The aim is to evaluate the cytotoxic effects of methotrexate-conjugated multi-walled carbon nanotubes at the biochemical and molecular levels.
Fabricated methotrexate-multi-walled carbon nanotube nanoconjugate.
Characterized the nanoconjugate for various properties.
Conducted in vitro assays to assess cytotoxic activity, hemocompatibility, and anti-angiogenic effects.
The MTX-MWCNT nanoconjugate exhibited significant cytotoxic activity.
Altered expression levels of BAX and BCL-2 were observed.
Demonstrated potential for anti-angiogenic effects through morphological alterations.

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Implication

Fabrication of methotrexate nanoconjugates demonstrates cytotoxic effects on biochemical targets, suggesting therapeutic potential.

Abstract

Fabrication and characterization of MTX-MWCNT nanoconjugate for evaluation of its cytotoxic activity, hemocompatibility, anti-angiogenic potential, molecular expression and morphological alterations through in vitro assays.

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Tiwari et al. (2026) studied this question.

synapsesocial.com/papers/69d895ea6c1944d70ce07074 https://doi.org/10.1039/d5ra08838k

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Fabrication of methotrexate conjugated multi-walled carbon nanotubes for the evaluation of cytotoxic potential at biochemical and molecular level modulating BAX , BCL-2 and telomerase expression

Key Points

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Implication

Abstract

Discussion

Cite This Study

Fabrication of methotrexate conjugated multi-walled carbon nanotubes for the evaluation of cytotoxic potential at biochemical and molecular level modulating BAX , BCL-2 and telomerase expression

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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