Dynamics of Circulatory HBcrAg and HBsAg After Nucleos(t)ide Analogue Cessation Using iTACT Assays to Predict Clinical Flares and HBsAg Loss

Key Points

• This research aims to explore how the dynamics of HBcrAg and HBsAg can predict clinical flare-ups and HBsAg loss after the discontinuation of nucleos(t)ide analogues.
• Analyzed HBcrAg and HBsAg levels using iTACT assays.
• Compared the predictive abilities of HBcrAg and HBsAg dynamics post-nucleoside analogue treatment cessation.
• Investigated the biological mechanisms associated with HBcrAg and HBsAg production.
• HBcrAg dynamics more accurately predicted clinical flares.
• HBsAg dynamics were better at predicting HBsAg loss.
• Findings support the complementary roles of both biomarkers in clinical practice.