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April 10, 2026JAMA Psychiatry3 citations

General Anesthesia and Discrete Components of Ketamine Neurophysiology

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BDBen DeverettDLDuan LiTLTheresa R. Lii

Key Points

  • To investigate how general anesthesia influences the neurophysiologic correlates of ketamine.
  • Cohort study design
  • Coadministration of ketamine with general anesthesia
  • Assessment of neurophysiologic correlates including θ and βγ waves
  • Coadministration selectively modulated θ neurophysiologic correlates of ketamine
  • No significant modulation of βγ neurophysiologic correlates was observed

Abstract

In this cohort study, coadministration of ketamine with GA selectively modulated the θ but not the βγ neurophysiologic correlates of ketamine. These findings suggest a potential method to explore the role of these components in the behavioral effects of ketamine.

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Cite This Study

Deverett et al. (2026) studied this question.

synapsesocial.com/papers/69d896046c1944d70ce07298https://doi.org/10.1001/jamapsychiatry.2026.0190
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ketamine can produce oscillatory dynamics by engaging mechanisms dependent on the kinetics of NMDA receptors2024 · 32 citations
  2. 2Deep posteromedial cortical rhythm in dissociation2020 · 298 citations
  3. 3Evidence that Subanesthetic Doses of Ketamine Cause Sustained Disruptions of NMDA and AMPA-Mediated Frontoparietal Connectivity in Humans2015 · 246 citations
  4. 4Paradoxical Emergence2017 · 68 citations
  5. 5Activation of Glutamatergic Neurotransmission by Ketamine: A Novel Step in the Pathway from NMDA Receptor Blockade to Dopaminergic and Cognitive Disruptions Associated with the Prefrontal Cortex1997 · 1,825 citations