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April 10, 2026JAMA Psychiatry2 citations

General Anesthesia and Discrete Components of Ketamine Neurophysiology

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BDBen DeverettDLDuan LiTLTheresa R. Lii

Key Points

  • To investigate how general anesthesia influences the neurophysiologic correlates of ketamine.
  • Cohort study design
  • Coadministration of ketamine with general anesthesia
  • Assessment of neurophysiologic correlates including θ and βγ waves
  • Coadministration selectively modulated θ neurophysiologic correlates of ketamine
  • No significant modulation of βγ neurophysiologic correlates was observed

Abstract

In this cohort study, coadministration of ketamine with GA selectively modulated the θ but not the βγ neurophysiologic correlates of ketamine. These findings suggest a potential method to explore the role of these components in the behavioral effects of ketamine.

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Cite This Study

Deverett et al. (2026) studied this question.

synapsesocial.com/papers/69d896046c1944d70ce07298https://doi.org/10.1001/jamapsychiatry.2026.0190
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