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General Anesthesia and Discrete Components of Ketamine Neurophysiology | Synapse

April 10, 2026

General Anesthesia and Discrete Components of Ketamine Neurophysiology

Key Points

To investigate how general anesthesia influences the neurophysiologic correlates of ketamine.
Cohort study design
Coadministration of ketamine with general anesthesia
Assessment of neurophysiologic correlates including θ and βγ waves
Coadministration selectively modulated θ neurophysiologic correlates of ketamine
No significant modulation of βγ neurophysiologic correlates was observed

Abstract

In this cohort study, coadministration of ketamine with GA selectively modulated the θ but not the βγ neurophysiologic correlates of ketamine. These findings suggest a potential method to explore the role of these components in the behavioral effects of ketamine.

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Cite This Study

Deverett et al. (Wed,) studied this question.

synapsesocial.com/papers/69d896046c1944d70ce07298 https://doi.org/https://doi.org/10.1001/jamapsychiatry.2026.0190