What does this research mean for the field?

Low-dose intravenous ketamine (<0.5 mg/kg) provides excellent analgesia, improves breathing, and stabilizes mood to prevent postoperative delirium, while higher doses or administration without benzodiazepines increase the risk of respiratory complications and delusional memories. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To review the dose-dependent respiratory, circulatory, and cortical effects of ketamine and define its risk-benefit profile in ambulatory anesthesia.

September 5, 2026Current Opinion in Anaesthesiology

Ketamine in ambulatory anesthesia: dose-dependent effects on breathing and cortical function

Q: What question did this study set out to answer?

To review the dose-dependent respiratory, circulatory, and cortical effects of ketamine and define its risk-benefit profile in ambulatory anesthesia.

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Authors

OAOmid Azimaraghi KWKaruna Wongtangman ASAiman Suleiman

Discussion

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Overview

Clinical review demonstrates dose-dependent respiratory and neurological effects of ketamine in ambulatory surgery, highlighting safety advantages of low-dose regimens.

Key Points

To review the dose-dependent respiratory, circulatory, and cortical effects of ketamine and define its risk-benefit profile in ambulatory anesthesia.
Narrative review synthesizing mechanistic pharmacology and clinical evidence on ketamine administration in ambulatory surgical settings.
Evaluation of neurochemical impacts on interneuron firing, pyramidal neuron disinhibition, respiratory muscle control, and neuropsychiatric outcomes.
Low-dose intravenous ketamine (<0.5 mg/kg) provides effective analgesia, enhances upper airway muscle drive, stabilizes hemodynamics, and helps prevent postoperative delirium.
Higher ketamine doses increase airway secretions and elevate the risk of respiratory complications, including laryngospasm and oxygen desaturation.
Administration to anxious patients without concurrent benzodiazepine premedication increases the incidence of frightening, delusional memories and emergence reactions.

Cite This Study

Azimaraghi et al. (2026) studied this question.

synapsesocial.com/papers/6a9bd4046b95aff0620eb447 https://doi.org/10.1097/aco.0000000000001705

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September 5, 2026Current Opinion in Anaesthesiology

Ketamine in ambulatory anesthesia: dose-dependent effects on breathing and cortical function

View Full Paper

Ask AI

Bookmark

Authors

OAOmid Azimaraghi KWKaruna Wongtangman ASAiman Suleiman

Discussion

Member takes

Overview

Clinical review demonstrates dose-dependent respiratory and neurological effects of ketamine in ambulatory surgery, highlighting safety advantages of low-dose regimens.

Key Points

To review the dose-dependent respiratory, circulatory, and cortical effects of ketamine and define its risk-benefit profile in ambulatory anesthesia.
Narrative review synthesizing mechanistic pharmacology and clinical evidence on ketamine administration in ambulatory surgical settings.
Evaluation of neurochemical impacts on interneuron firing, pyramidal neuron disinhibition, respiratory muscle control, and neuropsychiatric outcomes.
Low-dose intravenous ketamine (<0.5 mg/kg) provides effective analgesia, enhances upper airway muscle drive, stabilizes hemodynamics, and helps prevent postoperative delirium.
Higher ketamine doses increase airway secretions and elevate the risk of respiratory complications, including laryngospasm and oxygen desaturation.
Administration to anxious patients without concurrent benzodiazepine premedication increases the incidence of frightening, delusional memories and emergence reactions.

Cite This Study

Azimaraghi et al. (2026) studied this question.

synapsesocial.com/papers/6a9bd4046b95aff0620eb447 https://doi.org/10.1097/aco.0000000000001705

Also Consider

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