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July 31, 2025Frontiers in PsychiatryOpen Access

The impact of ketamine on cognitive outcomes in geriatric anesthesia: a comprehensive review

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Authors

SYS. Christine YouZLZhaohui Li

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Overview

Comprehensive review reveals ketamine may improve cognitive function in elderly patients, suggesting careful dosing is crucial.

Key Points

  • Low-dose ketamine (0.3–0.5 mg/kg) shows potential for protecting cognitive function in elderly patients during surgery.
  • Postoperative cognitive dysfunction and delirium are common in older surgical patients, leading to increased hospital stays.
  • Findings on ketamine's effects on cognition are inconsistent due to variability in study designs and patient populations.
  • Further large-scale, multicenter randomized controlled trials are necessary to determine the best dosing strategies for elderly patients.

Cite This Study

You et al. (2025) studied this question.

synapsesocial.com/papers/689a094be6551bb0af8cf463https://doi.org/10.3389/fpsyt.2025.1594730
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Preoperative ketamine administration for prevention of postoperative neurocognitive disorders after major orthopedic surgery in elderly patients: A multicenter randomized blinded placebo-controlled trial2024 · 12 citations
  2. 2Effect of ketamine/esketamine on postoperative delirium and cognitive dysfunctions: A systematic review and meta-analysis of randomised trials2025
  3. 3The impact of ketamine on delayed neurocognitive recovery in elderly patients undergoing spinal anaesthesia for orthopaedic procedures, a pilot study2024 · 1 citations
  4. 4A systematic review and meta-analysis on ketamine use and postoperative delirium in older patients undergoing spine or orthopedic surgery2026 · 5 citations
  5. 5The influence of low-dose s-ketamine on postoperative delirium and cognitive function in older adults undergoing thoracic surgery2024 · 11 citations