Preoperative ketamine administration for prevention of postoperative neurocognitive disorders after major orthopedic surgery in elderly patients: A multicenter randomized blinded placebo-controlled trial

Franck Verdonk; P.A. Lambert; Clément Gakuba; Anaïs Charles Nelson; Thomas Lescot; Fanny Garnier; Jean-Michel Constantin; Danielle Saurel; Sigismond Lasocki; Emmanuel Rineau; Pierre Diemunsch; Lucas Dreyfuss; B. Tavernier; Lucillia Bezu; Julien Josserand; Alexandre Mebazaa; Marine Coroir; Karine Nouette‐Gaulain; G. Maçouillard; Pauline Glasman; D. Lemesle; Vincent Minville; Philippe Cuvillon; Brice Gaudillière; Christophe Quesnel; Pierre Abdel-Ahad; Tarek Sharshar; Serge Molliex; Raphaël Gaillard; Jean Mantz

doi:10.1016/j.accpm.2024.101387

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Abstract

Preventive anesthetic impact on the high rates of postoperative neurocognitive disorders in elderly patients is debated. The Prevention of postOperative Cognitive dysfunction by Ketamine (POCK) study aimed to assess the effect of ketamine on this condition.

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Verdonk et al. (2024) studied this question.

synapsesocial.com/papers/68e6b4d5b6db64358763636d https://doi.org/10.1016/j.accpm.2024.101387

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Preoperative ketamine administration for prevention of postoperative neurocognitive disorders after major orthopedic surgery in elderly patients: A multicenter randomized blinded placebo-controlled trial

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Abstract

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Preoperative ketamine administration for prevention of postoperative neurocognitive disorders after major orthopedic surgery in elderly patients: A multicenter randomized blinded placebo-controlled trial

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Abstract

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