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November 18, 2025Indian Journal of AnaesthesiaOpen Access

Effect of ketamine/esketamine on postoperative delirium and cognitive dysfunctions: A systematic review and meta-analysis of randomised trials

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Authors

QGQian-Qian GuoXWXiao-Yong WeiZDZheng-Hua Dong

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Overview

Systematic review and meta-analysis show ketamine's benefit in reducing postoperative delirium, indicating variations in cognitive outcomes.

Key Points

  • To evaluate the impact of ketamine or esketamine on postoperative delirium and cognitive dysfunction.
  • Systematic search of databases for randomized controlled trials
  • Comparison of ketamine/esketamine versus placebo or no treatment
  • Quantified pooled estimates using odds ratios and confidence intervals
  • Utilized sensitivity analysis and meta-regression to identify effect modifiers
  • Ketamine reduced postoperative delirium risk (OR = 0.62)
  • Esketamine showed improved outcomes for delirium (OR = 0.68)
  • No significant effect of ketamine on cognitive dysfunction (OR = 0.41)
  • Secondary outcomes showed no significant differences in nausea/vomiting, pain, or length of stay

Cite This Study

Guo et al. (2025) studied this question.

synapsesocial.com/papers/6924fee6c0ce034ddc3517f1https://doi.org/10.4103/ija.ija_770_25
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of perioperative esketamine administration on the incidence of postoperative delirium: a systematic review and meta-analysis2026 · 3 citations
  2. 2Efficacy of intraoperative ketamine/esketamine in the prevention of postoperative delirium: a systematic review and meta-analysis.2025
  3. 3A systematic review and meta-analysis on ketamine use and postoperative delirium in older patients undergoing spine or orthopedic surgery2026 · 5 citations
  4. 4A comprehensive review and meta-analysis on the safety and efficacy of esketamine for emerging delirium in elderly patients2026
  5. 5The effects of esketamine on postoperative delirium in older patients with fragile brain function during the non-acute phase following lung cancer surgery: a randomized controlled trial2025