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August 11, 2025BMC GeriatricsOpen Access

The effects of esketamine on postoperative delirium in older patients with fragile brain function during the non-acute phase following lung cancer surgery: a randomized controlled trial

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Authors

HFHonglin FuJHJianda HuXZXuewei Zhang

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Overview

Randomized controlled trial finds esketamine lowers postoperative delirium in older patients undergoing lung surgery, suggesting potential benefits for recovery.

Key Points

  • Esketamine significantly reduces the incidence of postoperative delirium at 24 hours compared to control.
  • Postoperative serum levels of IL-6 and S100β were significantly lower in the esketamine group one day after surgery.
  • The study involved 108 older patients undergoing thoracoscopic radical lung cancer surgery, with random assignment to groups.
  • Patients receiving esketamine experienced shorter recovery times and improved postoperative oxygen levels.

Cite This Study

Fu et al. (2025) studied this question.

synapsesocial.com/papers/68a360e70a429f79733296e7https://doi.org/10.1186/s12877-025-06268-y
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of perioperative esketamine administration on the incidence of postoperative delirium: a systematic review and meta-analysis2026 · 3 citations
  2. 2A comprehensive review and meta-analysis on the safety and efficacy of esketamine for emerging delirium in elderly patients2026
  3. 3The effect of esketamine on perioperative neurocognitive dysfunction in elderly patients undergoing gastrointestinal tumor surgery: a randomized double-blind controlled study2025 · 1 citations
  4. 4The effect of esketamine on perioperative neurocognitive dysfunction in elderly patients who underwent gastrointestinal tumor surgery: a randomized double-blind controlled study2024 · 1 citations
  5. 5Effect of Esketamine on Postoperative Delirium in Patients Undergoing Cardiac Valve Replacement with Cardiopulmonary Bypass: A Randomized Controlled Trial2024 · 24 citations