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October 8, 2025Frontiers in MedicineOpen Access

The effect of esketamine on perioperative neurocognitive dysfunction in elderly patients undergoing gastrointestinal tumor surgery: a randomized double-blind controlled study

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Authors

XMXiaoyan MaJQJiarun QinMLMin Li

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Overview

Randomized controlled trial shows esketamine minimizes cognitive dysfunction and inflammation in elderly patients undergoing gastrointestinal tumor surgery.

Key Points

  • Elderly patients receiving esketamine had a lower incidence of perioperative neurocognitive dysfunction.
  • At 7 days post-surgery, the incidence of neurocognitive dysfunction was significantly lower in the esketamine group compared to the control group.
  • Assessment involved cognitive function tests at various intervals and serum inflammation markers before and after surgery.
  • Esketamine appears to enhance postoperative cognitive function and sleep quality by reducing inflammation and neuronal injury.

Cite This Study

Ma et al. (2025) studied this question.

synapsesocial.com/papers/68e5c1ba6950a706b22b552fhttps://doi.org/10.3389/fmed.2025.1653132
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The effect of esketamine on perioperative neurocognitive dysfunction in elderly patients who underwent gastrointestinal tumor surgery: a randomized double-blind controlled study2024 · 1 citations
  2. 2The effects of esketamine on postoperative delirium in older patients with fragile brain function during the non-acute phase following lung cancer surgery: a randomized controlled trial2025
  3. 3Effect of subanesthetic dose of esketamine on postoperative pain in elderly patients undergoing laparoscopic gastrointestinal tumor Surgery:A prospective, double-blind, randomized controlled trial2024 · 21 citations
  4. 4Effect of Perioperative Subanesthetic Dose of Esketamine on Postoperative Recovery Quality in Patients Undergoing Laparoscopic Gastrointestinal Surgery: A Randomised, Double-Blind, Controlled Trial2025 · 4 citations
  5. 5Effect of perioperative esketamine administration on the incidence of postoperative delirium: a systematic review and meta-analysis2026 · 3 citations