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September 24, 2025

Efficacy of intraoperative ketamine/esketamine in the prevention of postoperative delirium: a systematic review and meta-analysis.

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Authors

CCChengchuan ChenNZNa ZhouJHJ. Hou

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Overview

Systematic review examines the effect of ketamine/esketamine on postoperative delirium incidence, suggesting significant benefits.

Key Points

  • Intraoperative ketamine/esketamine may reduce postoperative delirium incidence by 29%, indicating its protective effects.
  • Meta-analysis demonstrated a relative risk of 0.71 for postoperative delirium with ketamine/esketamine use among 1571 participants.
  • Subanesthetic doses of ketamine/esketamine revealed a relative risk of 0.52 for preventing postoperative delirium, showing dose-response efficacy.
  • Esketamine was more effective in preventing postoperative delirium than ketamine, with specific benefits noted for elderly patients and those undergoing cardiac surgery.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68d6e14f8b2b6861e4c3fc35https://doi.org/10.1177/20451253251339378
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of ketamine/esketamine on postoperative delirium and cognitive dysfunctions: A systematic review and meta-analysis of randomised trials2025
  2. 2Effect of perioperative esketamine administration on the incidence of postoperative delirium: a systematic review and meta-analysis2026 · 3 citations
  3. 3A systematic review and meta-analysis on ketamine use and postoperative delirium in older patients undergoing spine or orthopedic surgery2026 · 5 citations
  4. 4A comprehensive review and meta-analysis on the safety and efficacy of esketamine for emerging delirium in elderly patients2026
  5. 5The influence of low-dose s-ketamine on postoperative delirium and cognitive function in older adults undergoing thoracic surgery2024 · 11 citations