What question did this study set out to answer?

To investigate the relationship between perioperative antidepressant use and the risk of opioid abuse following total joint arthroplasty.

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April 10, 2026Open Access

Perioperative Antidepressant Use Increases the Risk of Opioid Abuse After Total Joint Arthroplasty.

To investigate the relationship between perioperative antidepressant use and the risk of opioid abuse following total joint arthroplasty.
Conducted a retrospective analysis on opioid use in patients undergoing total joint arthroplasty.
Assessed antidepressant prescriptions during the perioperative period.
Evaluated opioid abuse rates post-surgery.
Patients using antidepressants showed higher rates of opioid abuse compared to those not using them.
The relationship indicates a significant risk factor for increased opioid dependence.
Findings suggest careful assessment of antidepressant use before and after surgery.

Level III. See Instructions for Authors for a complete description of levels of evidence.