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April 10, 2026Autophagy

SQSTM1/p62-mediated autophagy and antioxidation contribute to white spot syndrome virus pathogenesis in shrimp

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Authors

STSuttipong TungwaravutPJPhattarunda JareeHWHao Wang

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Overview

Demonstrates how SQSTM1/p62 mediates immune responses to WSSV in shrimp, suggesting mechanisms of viral evasion.

Key Points

  • The study aims to investigate the role of SQSTM1/p62 in the shrimp immune response to WSSV infection.
  • Examined the role of SQSTM1/p62 during WSSV infection in shrimp hemocytes.
  • Analyzed cellular localization of SQSTM1/p62 during infection.
  • Utilized silencing techniques to assess the effects of reduced SQSTM1 on viral load and shrimp survival.
  • Investigated interactions between SQSTM1/p62 and WSSV proteins.
  • WSSV infection activates SQSTM1-mediated selective autophagy in shrimp hemocytes.
  • Silencing of SQSTM1/p62 resulted in reduced viral load and increased shrimp survival.
  • SQSTM1/p62 was crucial in ROS regulation by interacting with KEAP1, impacting the NFE2L2/Nrf2 antioxidant pathway.

Cite This Study

Tungwaravut et al. (2026) studied this question.

synapsesocial.com/papers/69d8962d6c1944d70ce076eahttps://doi.org/10.1080/15548627.2026.2657545
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Also Consider

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  1. 1The white spot syndrome virus wsv156 protein hijacks Parkin-dependent mitophagy to promote viral infection2026
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  3. 3Pvf/Pvr signaling relieves white spot syndrome virus-induced lipid consumption to inhibit viral infection in shrimp.2026
  4. 4Infection and intracellular transport of white spot syndrome virus require the ESCRT machinery in shrimp2024 · 2 citations
  5. 5A Distinct Defense Strategy: The Molecular Basis of WSSV Tolerance in Macrobrachium nipponense Revealed by Comparative Transcriptomics with Litopenaeus vannamei2026 · 1 citations