Synapse
⌘+K
Synapse
PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
May 1, 2026

Pvf/Pvr signaling relieves white spot syndrome virus-induced lipid consumption to inhibit viral infection in shrimp.

View Full Paper
Ask AI
Bookmark
Share

Authors

ZCZi-Hua ChengPLPing-Ping LiuZFZe-Xuan Fan

Discussion

Loading...

Member takes

Overview

Randomized trial shows Pvf/Pvr signaling reduces lipid depletion from WSSV infection in shrimp, suggesting potential for aquaculture management.

Key Points

  • This research aims to clarify the role of Pvf/Pvr signaling in shrimp's antiviral response and lipid metabolism under WSSV infection.
  • Examined the effects of MjPvf2/MjPvr3 signaling on lipid metabolism during WSSV infection.
  • Utilized pharmacological inhibition of lipid synthesis to assess antiviral effects.
  • Analyzed lipid levels and viral replication rates post-intervention.
  • MjHSD promoted lipid synthesis and restored lipid levels, decreasing WSSV replication.
  • Pharmacological inhibition of lipid synthesis negated the antiviral effects of Pvf/Pvr signaling.
  • Significant insights were provided regarding lipid metabolism's influence on antiviral immunity.

Cite This Study

Cheng et al. (2026) studied this question.

synapsesocial.com/papers/69f443e8967e944ac5567101https://doi.org/10.1128/jvi.00182-26
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Invertebrate miRNA pva-small RNA-11881/pva-miR-11881 as a potential RNA-based therapeutic against white spot syndrome virus in infected shrimp2026 · 1 citations
  2. 2SQSTM1/p62-mediated autophagy and antioxidation contribute to white spot syndrome virus pathogenesis in shrimp2026
  3. 3Modulation of host lipid metabolism by virus infection leads to exoskeleton damage in shrimp2024 · 8 citations
  4. 4A Distinct Defense Strategy: The Molecular Basis of WSSV Tolerance in Macrobrachium nipponense Revealed by Comparative Transcriptomics with Litopenaeus vannamei2026 · 1 citations
  5. 5White Spot Syndrome Virus Envelope Protein <scp>VP</scp> 53 <scp>B</scp> Functions as a Trypsin Inhibitor and Interacts With Hemocyanin2026