ROS-accelerated quinone formation from gossypol in a dendritic AIE polymer enables synergistic type I photodynamic therapy and chemotherapy | Synapse
April 10, 2026
ROS-accelerated quinone formation from gossypol in a dendritic AIE polymer enables synergistic type I photodynamic therapy and chemotherapy
Key Points
The research aims to develop a polymer-based delivery system for gossypol to improve photodynamic therapy and chemotherapy outcomes.
Synthesis of TPAGH polymer as a photosensitizer for gossypol delivery
Creation of TPAGH-GS with pH-responsive release features
Evaluation of phototherapy enhancement through quinone-mediated reactions
Demonstrated improved delivery and release of gossypol using TPAGH-GS
Achieved enhanced phototherapeutic effects through quinone formation
Showed synergistic effects when combining photodynamic therapy with traditional chemotherapy
Abstract
A hyperbranched polymer photosensitizer, TPAGH, was synthesized for gossypol delivery, yielding TPAGH-GS with pH-responsive release and enhanced phototherapy via quinone-mediated Michael addition.