Patients with Takotsubo syndrome exhibit hypoconnectivity in brain regions associated with autonomic and limbic regulation, supporting a brain-heart axis pathophysiology.
For the first time, we demonstrate hypoconnectivity of central brain regions associated with autonomic functions and regulation of the limbic system in patients with TTS. These findings suggest that autonomic-limbic integration might play an important role in the pathophysiology and contribute to the understanding of TTS.
Templin et al. (2019) studied this question.