Altered limbic and autonomic processing supports brain-heart axis in Takotsubo syndrome

Figure 1. Takotsubo syndrome-related hypoconnectivity among central nervous brain structures controlling para- and sympathetic functions as well as regions associated with the default mode network and limbic system. Shown are the more conservatively thresholded subnetworks with reduced resting state functional connectivity in Takotsubo syndrome patients compared with healthy control women. Colour bars represent the set t-value of the connections between which the two groups differ in connectivity strength. The more liberally thresholded subnetworks and detailed information of the nodes and connections involved are shown in the Supplementary materials online. (A) At the higher set threshold (t = 2.30), the Takotsubo syndrome-related parasympathetic-associated hypoconnected subnetwork is composed of seven edges distributed over eight nodes (P = 0.003, FWE-corrected, 5000 permutations). A detailed description of the nodes constituting the subnetworks can be found in Supplementary material online, Table S3. Among these nodes are the right amygdala, left and right hippocampus, left and right middle and superior temporal gyrus, left primary motor cortex and the left supramarginal/angular gyrus,…