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Synapse
November 10, 2015Critical Care225 citationsOpen Access

Propofol infusion syndrome: a structured review of experimental studies and 153 published case reports

AKAdéla KrajčováPWPetr WaldaufMAMichal Anděl

Structured PICO

What are the clinical features and diagnostic challenges of propofol infusion syndrome?

P
Population
153 published case reports and experimental studies of propofol infusion syndrome (PRIS)
I
Intervention
Propofol infusion
O
Outcome
Clinical features and diagnosis of propofol infusion syndromesafety

Propofol infusion syndrome can occur at low doses (<4 mg/kg/hr) and is challenging to diagnose because typical features are often absent and cardiac changes occur late.

Abstract

PRIS can develop with propofol infusion 95 %) missing and others (arrhythmia, electrocardiographic changes) occur late.

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Cite This Study

Krajčová et al. (2015) studied this question.

synapsesocial.com/papers/69d94b8f8988aeabbe684b94https://doi.org/10.1186/s13054-015-1112-5
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Propofol infusion in children: when does an anesthetic tool become an intensive care liability?2004 · 74 citations
  2. 2Propofol infusion in children.1992 · 35 citations
  3. 3Metabolic Acidosis Associated with Propofol in the Absence of Other Causative Factors2004 · 93 citations
  4. 4Postburn trauma insulin resistance and fat metabolism2007 · 106 citations
  5. 5[Effect of prolonged infusion of propofol on the liver mitochondria respiratory function in rabbits].2010 · 5 citations