Why the study?
What are the clinical features and diagnostic challenges of propofol infusion syndrome?
What are the clinical features and diagnostic challenges of propofol infusion syndrome?
Propofol infusion syndrome can occur at low doses (<4 mg/kg/hr) and is challenging to diagnose because typical features are often absent and cardiac changes occur late.
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Vigilance for atypical PRIS needed even at propofol <4 mg/kg/h; leaves open prospective validation of revised diagnostic criteria.
PRIS can develop with propofol infusion <4 mg/kg per hour and its diagnosis may be challenging as some of its typical features (hypertriglyceridaemia, fever, hepatomegaly, heart failure) are often (>95 %) missing and others (arrhythmia, electrocardiographic changes) occur late.
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Krajčová et al. (2015) studied this question.
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