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February 23, 2018Nature Communications87 citationsOpen Access

Genetic study links components of the autonomous nervous system to heart-rate profile during exercise

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Population

58,818 UK Biobank individuals

Design

Cohort

Authors

NVNiek VerweijYVYordi J. van de VegtePHPim van der Harst

Discussion

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Overview

Loci linked to exercise HR dynamics extend autonomic genetic insights; leaves open causal effects on mortality or clinical utility.

Structured PICO

P
Population
58,818 UK Biobank individuals
O
Outcome
Heart rate (HR) increase and HR recovery during and after exercisesurrogate

A large-scale genome-wide analysis identified 25 independent SNPs associated with heart rate increase and recovery during exercise, highlighting the genetic role of the autonomic nervous system in heart rate response.

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Verweij et al. (2018) studied this question.

synapsesocial.com/papers/69d962505e5bcb4e3b835f57https://doi.org/10.1038/s41467-018-03395-6
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