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January 21, 2011DiabetesOpen Access

Smad3 Deficiency in Mice Protects Against Insulin Resistance and Obesity Induced by a High-Fat Diet

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Population

Mice on a high-fat diet

Design

Preclinical

Authors

CTChek Kun TanNLNicolas LeuenbergerMTMing Tan

Discussion

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Overview

Does not support clinical use; leaves open Smad3 as therapeutic target in human metabolic disease.

Structured PICO

P
Population
Mice on a high-fat diet
I
Intervention
Smad3 deficiency
O
Outcome
Insulin resistance and obesitysurrogate

Smad3 deficiency protects mice against high-fat diet-induced obesity and insulin resistance, suggesting it as a potential therapeutic target.

Cite This Study

Tan et al. (2011) studied this question.

synapsesocial.com/papers/69d965e794760e72e6a3c4b5https://doi.org/10.2337/db10-0801
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