Does antibiotic prophylaxis with second- or third-generation cephalosporins improve outcomes in patients undergoing cardiac surgery?
Second- or third-generation cephalosporins are supported for cardiac surgery prophylaxis, with a possible advantage to extending prophylaxis up to 48 hours post-operatively.
Evidence supports second- or third-generation cephalosporins for cardiac surgery prophylaxis and points at a possible advantage of prophylaxis prolongation up to 48 h post-operatively.
Lador et al. (2011) studied this question.