June 11, 2019JAMA320 citationsOpen Access
Association Between Transcatheter Aortic Valve Replacement for Bicuspid vs Tricuspid Aortic Stenosis and Mortality or Stroke
Structured PICO
Does transcatheter aortic valve replacement for bicuspid aortic stenosis reduce mortality or stroke in patients with aortic stenosis compared to transcatheter aortic valve replacement for tricuspid aortic stenosis?
P
Population
Propensity-matched patients who had undergone transcatheter aortic valve replacement for aortic stenosis
I
Intervention
Transcatheter aortic valve replacement for bicuspid aortic stenosis
C
Comparator
Transcatheter aortic valve replacement for tricuspid aortic stenosis
O
Outcome
30-day or 1-year mortality and 30-day risk for strokehard clinical
TAVR for bicuspid aortic stenosis is associated with similar 1-year mortality but a higher 30-day stroke risk compared to TAVR for tricuspid aortic stenosis.
Abstract
In this preliminary, registry-based study of propensity-matched patients who had undergone transcatheter aortic valve replacement for aortic stenosis, patients with bicuspid vs tricuspid aortic stenosis had no significant difference in 30-day or 1-year mortality but had increased 30-day risk for stroke. Because of the potential for selection bias and the absence of a control group treated surgically for bicuspid stenosis, randomized trials are needed to adequately assess the efficacy and safety of transcatheter aortic valve replacement for bicuspid aortic stenosis.