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November 17, 2015JNCI Journal of the National Cancer Institute689 citationsOpen Access

PDL1 Regulation by p53 via miR-34

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MCMaría Angélica CortezCICristina IvanDVDavid R. Valdecanas

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Abstract

We identified a novel mechanism by which tumor immune evasion is regulated by p53/miR-34/PDL1 axis. Our results suggest that delivery of miRNAs with standard therapies, such as XRT, may represent a novel therapeutic approach for lung cancer.

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Cite This Study

Cortez et al. (2015) studied this question.

synapsesocial.com/papers/69d99ff8e6ab964fb083601chttps://doi.org/10.1093/jnci/djv303
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Requirement for p53 and p21 to Sustain G 2 Arrest After DNA Damage1998 · 2,819 citations
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  4. 4Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression2009 · 517 citations
  5. 5MicroRNA-Mediated Down-Regulation of M-CSF Receptor Contributes to Maturation of Mouse Monocyte-Derived Dendritic Cells2013 · 31 citations