Does the dose of aspirin affect efficacy and bleeding risk when used alone or with clopidogrel in patients with acute coronary syndromes?
The optimal daily dose of aspirin in patients with ACS is between 75 and 100 mg, as higher doses increase bleeding risk without improving efficacy.
In patients with ACS, adding clopidogrel to aspirin is beneficial regardless of aspirin dose. Bleeding risks increase with increasing aspirin dose, with or without clopidogrel, without any increase in efficacy. Our findings suggest that the optimal daily dose of aspirin may be between 75 and 100 mg, with or without clopidogrel.
Peters et al. (2003) studied this question.
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