Effect of Mechanical Ventilation on Inflammatory Mediators in Patients With Acute Respiratory Distress Syndrome

Key Points

• This research aims to investigate how mechanical ventilation affects inflammatory mediators in patients with acute respiratory distress syndrome.
• Examined the cytokine response induced by mechanical ventilation.
• Evaluated strategies to minimize lung overdistention and recruitment/derecruitment.
• Future studies suggested to determine clinical end point improvements.
• Cytokine response was noted with mechanical ventilation.
• Potential physiological improvements indicated may require further clinical endpoint analysis.
• Future research needed to confirm associations with clinical outcomes.